Dr. Bocci, Nancy, Dr. Nabil (From Left)At 1st Ozone Conference in Egypt.

The dual action of ozone on the skin

By G.. Valacchi, V. Fortino and V. Bocci


Department of Physiology, University of Siena, Siena53100, Italy
Department Internal Medicine, School of Medicine, University of California Davis, DavisCA95616, U.S.A.

Topical application
Interestingly, in spite of its instability, the O3 molecule can be stabilized as an ozonide between the double bonds of a monounsaturated fatty acid such as oleic acid. As a consequence, ozonated Olive Oil and Jojoba Oil remains stable for 2 years at 4℃. This preparation is proving to be ideal for the topical use of O3 in the treatment of chronically infected cutaneous and mucosal areas of the body.

O3 is widely recognized as one of the best bactericidal, antiviral and antifungal agents and therefore it is profitably and practically employed as ozonated Olive Oil and Jojoba Oil with well defined peroxide contents. The ozonated oil is now used topically for the treatment of war wounds, anaerobic infections, herpetic infections, trophic ulcers and burns, cellulitis, abscesses, anal fissures, decubitus ulcers (bed sores), fistulae, fungal diseases, furunculosis, gingivitis and vulvovaginitis. Matsumoto et al. tested the efficacy of the ozonated oil in the treatment of fistulae and chronic surgical wounds and, in a series of 28 patients; the ozonated oil was fully effective in 27 cases without side-effects. Even radiodermatitis lesions in patients with cancer have been found to be beneficially influenced by exposure to O3 but far better results could be achieved with the simple application of ozonated oil.

Biological and clinical studies on the effects of O3 on the skin have shown that O3 can be either toxic, or safe at the point of use as a real drug, depending upon its dosage, length of exposure and the antioxidant capacity of the tissue exposed.

The ambivalent character of O3 has been likened to the Latin god Janus; indeed O3 is useful in the stratosphere but is toxic in the troposphere because of its chronic effects on the respiratory system, skin and mucosa.

In the other hand, it has recently been observed that Olive Oil and Jojoba Oil, which during ozonation traps O3 in the form of a stable ozonide, when applied to all sorts of acute and chronic cutaneous infections, slowly release O3 which, in comparison with conventional creams, displays effective disinfectant and stimulatory activities that lead to rapid healing. The dual behavior of O3 fits well the concept of "hormesis"  that says the exposure of a living organism to a very low level of an agent harmful at high or chronic levels induces an adaptive and beneficial response.

This article is for your educational purposes only.
For medical treatment and advice be sure to consult with your physician.