Dr. Bocci, Nancy, Dr. Nabil (From Left)At 1st Ozone Conference in Egypt.
The dual action of ozone on the skin
By G.. Valacchi, V. Fortino and V. Bocci
TFOR EDUCATIONAL PURPOSES ONLY
Department of Physiology, University of Siena, Siena53100, Italy
Department Internal Medicine, School of Medicine, University of California Davis, DavisCA95616, U.S.A.
Interestingly, in spite of its instability, the O3
molecule can be stabilized as an ozonide between the double bonds of
a monounsaturated fatty acid such as oleic acid. As a consequence,
ozonated Olive Oil and Jojoba Oil remains stable for 2 years at 4℃.
This preparation is proving to be ideal for the topical use of O3
in the treatment of chronically infected cutaneous and mucosal areas
of the body.
O3 is widely recognized as one of the
best bactericidal, antiviral and antifungal agents and therefore it
is profitably and practically employed as ozonated Olive Oil and
Jojoba Oil with well defined peroxide contents. The ozonated oil is
now used topically for the treatment of war wounds, anaerobic
infections, herpetic infections, trophic ulcers and burns,
cellulitis, abscesses, anal fissures, decubitus ulcers (bed sores),
fistulae, fungal diseases, furunculosis, gingivitis and
vulvovaginitis. Matsumoto et al. tested the efficacy of the ozonated
oil in the treatment of fistulae and chronic surgical wounds and, in
a series of 28 patients; the ozonated oil was fully effective in 27
cases without side-effects. Even radiodermatitis lesions in patients
with cancer have been found to be beneficially influenced by
exposure to O3 but far better results could be achieved
with the simple application of ozonated oil.
Biological and clinical studies on the effects of
O3 on the skin have shown that O3 can be
either toxic, or safe at the point of use as a real drug, depending
upon its dosage, length of exposure and the antioxidant capacity of
the tissue exposed.
The ambivalent character of O3 has
been likened to the Latin god Janus; indeed O3 is useful
in the stratosphere but is toxic in the troposphere because of its
chronic effects on the respiratory system, skin and mucosa.
In the other hand, it has recently been observed
that Olive Oil and Jojoba Oil, which during ozonation traps O3
in the form of a stable ozonide, when applied to all sorts of acute
and chronic cutaneous infections, slowly release O3
which, in comparison with conventional creams, displays effective
disinfectant and stimulatory activities that lead to rapid healing.
The dual behavior of O3 fits well the concept of "hormesis"
that says the exposure of a living organism to a very low level of
an agent harmful at high or chronic levels induces an adaptive and